MyBioSource.com's Anti-Hu CD205 Purified is a Mouse monoclonal antibody. The Anti-Hu CD205 Purified Antibody was generated using LY75, lymphocyte antigen 75, and LY75-CD302 as the antigen. It reacts with Human. This antibody has been shown to work in applications such as: Flow Cytometry, Immunohistochemistry, Immunohistochemistry - frozen, and Western Blot.
Description
CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. CD205 is responsible for uptake and processing of captured antigens for dendritic cells